asthma- U get thicker muscle walls, mucus in lumen, bronchoconstriction which causes folded walls
COPD- chronic bronchitis affecting bronchi, mucus hyper secretion due to increased goblet cells and hyperplasia of them so they’re bigger- cilia can’t move as well and there’s less of them- causes mucus build up
COPD people/smokers get fibrosis in airway which narrows airway lumen- causes small airway obstruction (bronchioles) leading to wheezy patients
different people have differing severities of the 3 above features of COPD
In COPD, alveolar attachments also degrade, making alveoli collapse more leading to more airway obstruction
To check if someone has been smoking, we can check for metabolites in the pee