• Why the change causes altered electrophoresis?
• Why only some of the alpha 1 (I) collagen chains affected?
• What is osteogenesis imperfecta and what causes it?
• What would a change from glycine in collagen to cysteine do?
• What happens if you're heterozygous for a mutation that causes abnormal collagen chains?
• How is bone affected?
• What else can the disease affect?
• How would we check for the disease in foetuses?