• Define T2DM
• At what ages can T2DM develop and how has our view of this changed?
• What is the prevalence of T2DM like now and how is it predicted to be in the future?
• Stages of development of T2DM graph
• Graph of glucose tests and normal/T2DM levels
• What are the beta cell function levels at when you're diagnosed with T2DM?
• What is relative insulin deficiency in T2DM?
• What happens in long duration T2DM?
• What is the pathophysiology of T2DM?
• What is a hyperglycaemic clamp?
• What is the problem with HGO in T2DM?
• What does the relationship between insulin sensitivity (and thus resistance) and insulin secretion look like in normal vs T2DM people?
• What are the consequences of insulin resistance in:
• What does excess of inflammatory adipokines do to T2DM patients?
• What is monogenic diabetes?
• How is T2DM polygenic?
• How does genetic and environmental risk interact in the chance of development of T2DM?
• What do genome wide association studies of T2DM show?
• What is the role of obesity in T2DM?
• What role do perturbations in gut microbiota have on T2DM cases?